Razor Host

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A. Process Analytical Techniques B. Process Monitoring (on-line, in-line, non-invasive) C. Multivariate Data Analysis D. Process Modelling E. Process Control

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B1 Reaction monitoring B2 Monitoring of drying and powder blending B3 Biological process analysis B4 Microreactors and flow chemistry

title year authors journal volume pages Categories Actions
A heuristic approach to handling missing data in biologics manufacturing databases 2019 Mante, J., Gangadharan, N., Sewell, D. J., Turner, R., Field, R., Oliver, S. G., . . . Dikicioglu, D. Bioprocesses and Biosystems Engineering 42 (4) 657-663 B3 Biological process analysis, D3 Performance monitoring DOI
A micro reactor for the study of biotransformations by a cross-linked gamma-lactamase enzyme 2009 Hickey AM, Ngamsom B, Wiles C, Greenway GM, Watts P and Littlechild JA 4(4) 510-516 B3 Biological process analysis, B4 Microreactors and flow chemistry DOI
Biofluid analysis and classification using IR and 2D-IR spectroscopy 2021 Rutherford Samantha H., Nordon Alison, Hunt Neil T., Baker Matthew J. Chemometrics and Intelligent Laboratory Systems 217 104408 B3 Biological process analysis DOI
Biomass composition: the “elephant in the room” of metabolic modelling 2015 Dikicioglu Duygu, Kirdar Betul, Oliver Stephen G. Metabolomics 11 1690-1701 B3 Biological process analysis, D2 Multi-block, predictive and multi-scale modelling methods DOI
CamOptimus: a tool for exploiting complex adaptive evolution to optimize experiments and processes in biotechnology 2017 Cankorur-Cetinkaya Ayca, Dias Joao M. L., Kludas Jana, Slater Nigel K. H., Rousu Juho, Oliver Stephen G., Dikicioglu Duygu Microbiology 163 829-839 B3 Biological process analysis, D3 Performance monitoring DOI
CLUSTERnGO: a user-defined modelling platform for two-stage clustering of time-series data 2016 Fidaner Isik Baris, Cankorur-Cetinkaya Ayca, Dikicioglu Duygu, Kirdar Betul, Cemgil Ali Taylan, Oliver Stephen G. Bioinformatics 32 388-397 C1 Multivariate data analysis, B3 Biological process analysis DOI
Combined shifted-excitation Raman difference spectroscopy and support vector regression for monitoring the algal production of complex polysaccarides 2013 Noack K, Eskofier B, Kiefer J, Dilk C, Bilow G, Schirmer M, Buchholz R, Leipertz A Analyst 138 5639-5646 B3 Biological process analysis DOI
Combining model structure identification and hybrid modelling for photo-production process predictive simulation and optimisation 2020 Zhang Dongda, Savage Thomas R., Cho Bovinille A. Biotechnology and Bioengineering 117 3356-3367 B3 Biological process analysis DOI
Comparison of physics-based and data-driven modelling techniques for dynamic optimisation of fed-batch bioprocesses 2019 Del Rio-Chanona Ehecatl Antonio, Ahmed Nur Rashid, Wagner Jonathan, Lu Yinghua, Zhang Dongda, Jing Keju Biotechnology and Bioengineering 116 2971-2982 B3 Biological process analysis DOI
Development of a gas-phase Raman instrument using a hollow core anti-resonant tubular fibre 2021 Brooks William S.M., Partridge Matthew, Davidson Ian A.K., Warren Charles, Rushton George, Large Joseph, Wharton Michael, Storey Jonathan, Wheeler Natalie V., Foster Michael J. Journal of Raman Spectroscopy 52 1772-1782 B2 Monitoring of drying and powder blending, B3 Biological process analysis, B4 Microreactors and flow chemistry, B1 Reaction monitoring, A1. Non-invasive Raman spectrometry, A5. ATR-MIR spectrometry DOI
Development of a high throughput screening tool for biotransformations utilising a thermophilic L-aminoacylase enzyme 2010 Ngamsom B, Hickey AM, Greenway GM, Littlechild JA, Watts P and Wiles C J. Mol. Catal. B Enzym. 63 81-86 B3 Biological process analysis, B4 Microreactors and flow chemistry DOI
Dynamic modeling and optimization of sustainable algal production with uncertainty using multivariate Gaussian processes 2018 Bradford Eric, Schweidtmann Artur M., Zhang Dongda, Jing Keju, del Rio-Chanona Ehecatl Antonio Computers & Chemical Engineering 118 143-158 B3 Biological process analysis DOI
Dynamic modelling of the killing mechanism of action by virus-infected yeasts 2019 Sheppard Sean, Dikicioglu Duygu Journal of The Royal Society Interface 16 20190064 B3 Biological process analysis, D1 Kinetic modelling DOI
Dynamic Proteomic Profiling of Extra-Embryonic Endoderm Differentiation in Mouse Embryonic Stem Cells 2015 Mulvey Claire M., Schröter Christian, Gatto Laurent, Dikicioglu Duygu, Fidaner Isik Baris, Christoforou Andy, Deery Michael J., Cho Lily T. Y., Niakan Kathy K., Martinez-Arias Alfonso, Lilley Kathryn S. STEM CELLS 33 2712-2725 C1 Multivariate data analysis, B3 Biological process analysis DOI
Extension of the yeast metabolic model to include iron metabolism and its use to estimate global levels of iron-recruiting enzyme abundance from cofactor requirements 2019 Dikicioglu Duygu, Oliver Stephen G. Biotechnology and Bioengineering 116 610-621 D2 Multi-block, predictive and multi-scale modelling methods, B3 Biological process analysis DOI
Extracellular acidity and oxygen availability conjointly control eukaryotic cell growth via modulation of cytoplasmic translation. 2019 Dikicioglu, D Turkish Journal of Biochemistry B3 Biological process analysis, C1 Multivariate data analysis DOI
Fermentation process tracking through enhanced spectral calibration modeling 2007 Triadaphillou S, Martin E, Montague G, Nordon A, Jeffkins P and Stimpson S Biotechnol. Bioeng. 97 554-567 B3 Biological process analysis, C2 Calibration transfer/model maintenance DOI
Flux Balance Analysis of a Genome-Scale Yeast Model Constrained by Exometabolomic Data Allows Metabolic System Identification of Genetically Different Strains 2007 Cakir T., Efe C., Dikicioglu D., Hortacsu A., Kirdar B., Oliver S.G. Biotechnology Progress 23 320-326 D2 Multi-block, predictive and multi-scale modelling methods, B3 Biological process analysis DOI
Formal model of Parkinson’s disease neurons unveils possible causality links in the pathophysiology of the disease 2020 Nadal Morgane, Schierle Gabriele S. Kaminski, Dikicioglu Duygu D1 Kinetic modelling, B3 Biological process analysis DOI
Handling variability and incompleteness of biological data by flexible nets: a case study for Wilson disease 2018 Júlvez Jorge, Dikicioglu Duygu, Oliver Stephen G. npj Systems Biology and Applications 4 B3 Biological process analysis, D1 Kinetic modelling DOI
How yeast re-programmes its transcriptional profile in response to different nutrient impulses 2011 Dikicioglu Duygu, Karabekmez Erkan, Rash Bharat, Pir Pinar, Kirdar Betul, Oliver Stephen G BMC Systems Biology 5 148 C1 Multivariate data analysis, B3 Biological process analysis DOI
Hybrid physics-based and data-driven modeling for bioprocess online simulation and optimization 2019 Zhang Dongda, Del Rio-Chanona Ehecatl Antonio, Petsagkourakis Panagiotis, Wagner Jonathan Biotechnology and Bioengineering 116 2919-2930 B3 Biological process analysis DOI
Improving the accuracy of flux balance analysis through the implementation of carbon availability constraints for intracellular reactions 2019 Lularevic M, Racher AJ, Jaques C, Kiparissides A Biotechnology and BioEngineering 116 2339-2352 B3 Biological process analysis DOI
In situ monitoring of the seed stage of a fermentation process using non-invasive NIR spectrometry 2008 Nordon A, Littlejohn D, Dann AS, Jeffkins PA, Richardson MD and Stimpson SL Analyst 5 660-666 B3 Biological process analysis DOI
Integration of Metabolic Modeling and Phenotypic Data in Evaluation and Improvement of Ethanol Production Using Respiration-Deficient Mutants of Saccharomyces cerevisiae 2008 Dikicioglu Duygu, Pir Pinar, Onsan Z. Ilsen, Ulgen Kutlu O., Kirdar Betul, Oliver Stephen G. Applied and Environmental Microbiology 74 5809-5816 C1 Multivariate data analysis, B3 Biological process analysis DOI
Integration of Metabolic Modeling and Phenotypic Data in Evaluation and Improvement of Ethanol Production Using Respiration-Deficient Mutants of Saccharomyces cerevisiae 2008 Dikicioglu Duygu, Pir Pinar, Onsan Z. Ilsen, Ulgen Kutlu O., Kirdar Betul, Oliver Stephen G. Applied and Environmental Microbiology 74 5809-5816 D2 Multi-block, predictive and multi-scale modelling methods, B3 Biological process analysis DOI
Investigating the feasibility of mid infrared spectroscopy for monitoring an industrial de-racemization biotransformation process 2012 Gardner P, Arnold SA, Brown F, Carr R, Nordon A, Harvey LM and McNeil B. Analytica Chimica Acta, 779 50-55 B3 Biological process analysis, A5. ATR-MIR spectrometry DOI
Metabolic modeling to identify engineering targets forKomagataella phaffii: The effect of biomass composition on gene target identification 2017 Cankorur-Cetinkaya Ayca, Dikicioglu Duygu, Oliver Stephen G. Biotechnology and Bioengineering 114 2605-2615 D2 Multi-block, predictive and multi-scale modelling methods, B3 Biological process analysis DOI
Metabolic response to Parkinson's disease recapitulated by the haploinsufficient diploid yeast cells hemizygous for the adrenodoxin reductase gene 2019 Dikicioglu Duygu, Coxon James W. M. T., Oliver Stephen G. Molecular Omics 15 340-347 B3 Biological process analysis, C1 Multivariate data analysis DOI
Saccharomyces cerevisiae adapted to grow in the presence of low-dose rapamycin exhibit altered amino acid metabolism 2018 Dikicioglu Duygu, Dereli Eke Elif, Eraslan Serpil, Oliver Stephen G., Kirdar Betul Cell Communication and Signaling 16 C1 Multivariate data analysis, B3 Biological process analysis DOI
Short- and long-term dynamic responses of the metabolic network and gene expression in yeast to a transient change in the nutrient environment 2012 Dikicioglu Duygu, Dunn Warwick B., Kell Douglas B., Kirdar Betul, Oliver Stephen G. Molecular BioSystems 8 1760 C1 Multivariate data analysis, B3 Biological process analysis DOI
Towards better understanding of an industrial cell factory investigating the feasibility of real-time metabolic flux analysis in Pichia pastoris 2013 Fazenda M, Dias J, Harvey L, Nordon A, Edrada-Ebel R, Littlejohn D and NcNeil B Microbial Cell Factories 12:51 B3 Biological process analysis DOI
Yeast cells with impaired drug resistance accumulate glycerol and glucose 2014 Dikicioglu, D., Oc, S., Rash, B. M., Dunn, W. B., Pir, P., Kell, D. B., . . . Oliver, S. G Molecular Biosytems 10 (1) 93-102 C1 Multivariate data analysis, B3 Biological process analysis DOI