Webinar on
Process
Analytical Technology (PAT) Strategies to
Support
Batch Oral Dosage Manufacturing
Vladimir
Villanueva-Lopez, James Kimber, Giuseppe Cogoni, David Wilsdon.
Pfizer Inc,
Pfizer Research and Development, Analytical R&D, Groton, US
11th
March 2026 at 2pm EDT 6pm, UK time
The implementation of Process Analytical Technology (PAT) in batch
manufacturing provides formulators with critical insights into the impact of
various formulation variables on material behavior, particularly regarding
material segregation during development. Utilizing in-line spectroscopic
methods enables real-time monitoring of content uniformity, generating more comprehensive
real-time data on formulation performance, and facilitating accelerated
development timelines. This approach also significantly reduces the reliance on
extensive offline laboratory testing, such as liquid chromatography, making
development faster and more environmentally friendly.
Traditionally, In-line PAT sampling involves
inserting a Near-Infrared (NIR) probe into a Feed Frame Interface port
on the tablet press 1–3 , where spectra are collected
moments before compaction into tablets. While this approach is well established
and widely understood, it necessitates a tablet press equipped with an
interface port for the NIR probe. As an alternative, a newly developed Universal
PAT Interface has been engineered for ease of installation, permitting
direct insertion of the NIR probe into the feed chute between the feed frame
and hopper. This universal interface allows for straightforward implementation
in both batch and continuous manufacturing environments, without requiring
modifications to the tablet press.
This presentation compares two methods
used concurrently to collect in-line PAT measurements during tablet production,
aiming to study powder dynamics. Step change experiments were performed to
estimate the mean residence time for each PAT interface and to evaluate sample
presentation. The universal PAT interface demonstrates a short residence time
of less than 15 seconds which suggests minimal mixing or shear is introduced and
ensures a representative sampling from the powder stream. Its interchangeable
use in continuous and batch manufacturing highlights its versatility and
suitability for a range of unit operations involving powder stream sampling for
content uniformity assessments.
This webinar will last no
longer than one hour.
The webinar is for CPACT
members only.
Please register directly
at https://universityofstrathclyde.webex.com/weblink/register/r846e9f02d612940b8d92a513d42e334a